Clinical Advantages vs. Conventional Ferrous Sulfate
2x
Improved Iron Absorption
6x
Improved GI Tolerability
4x
Improved Treatment Adherence
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The Clinical Challenge
Supplemental iron can cause significant GI irritation and side effects when the iron form has poor bioavailability due to the oxidation of iron to the ferric state (Fe³⁺) in the stomach. Clinical research reports that up to 80% of people can experience GI side effects like abdominal cramping, nausea, constipation or diarrhea when taking low-bioavailability forms, resulting in a 50% early discontinuation rate.
Poor Absorption
Most conventional ferrous iron supplements get oxidized into ferric iron (Fe³⁺), which is insoluble at normal intestinal pH.
When iron is not efficiently absorbed, it remains in the gut in its oxidized form rather than being transported into the body, contributing to GI irritation and limiting how much iron the body can use.
Poor Tolerance
Up to 80% of patients experience gastrointestinal side effects with conventional ferrous sulfate supplements, including nausea, constipation, abdominal pain, and diarrhea.
These effects can make ongoing iron supplementation difficult to tolerate.
Poor Adherence
Because unabsorbed iron often leads to gastrointestinal side effects, many patients find it difficult to stay consistent with conventional iron supplementation.
Up to 50% of patients discontinue iron supplements early, which can limit adequate repletion.
Why TruFerra™ is Different
TruFerra™ is designed with formulation first — prioritizing absorption and daily tolerance to address the limitations of standard iron.
Delivers Enhanced Bioavailability
TruFerra™ uses a patent-protected whey protein microsphere (ST1406
®) that maintains iron in its absorbable ferrous (Fe²⁺) form and delivers it directly to DMT-1 transporters in the duodenum—the body's primary iron absorption site.
®) that maintains iron in its absorbable ferrous (Fe²⁺) form and delivers it directly to DMT-1 transporters in the duodenum—the body's primary iron absorption site.
Clinically Validated Absorption
In a prospective, randomized human clinical study, TruFerra™ demonstrated more than twice the iron absorption of conventional ferrous sulfate, with the greatest benefit observed in iron-deficient individuals.
Improved Gastrointestinal Tolerability
TruFerra™ demonstrated six times fewer gastrointestinal adverse events than previous oral iron, including nausea, constipation, abdominal pain, and diarrhea.
Better Patient Adherence
TruFerra™ is better tolerated and patients were four times more likely to remain adherent compared to previous oral iron supplementation—leading to more reliable iron repletion.
Engineered for Absorption & Tolerability
Together, these three components form a precision delivery system — not just iron in a capsule.
Ferrous Iron (Fe²⁺)
Maintains iron in its most absorbable form
Targeted Delivery (Whey Protein Microspheres)
Patent-protected formula stabilizes and delivers iron to DMT-1 transporters in the duodenum for optimal absorption and minimal gut irritation
Clinically Proven to Increase Iron Stores
Shown in clinical research to increase iron stores by more than 100% in six weeks with iron levels maintained at 100% or more at 12 weeks
The TruFerra™ Difference
TruFerra™ is designed with formulation first—prioritizing absorption and daily tolerance to address the limitations of conventional ferrous sulfate.
Common Clinical Questions
TruFerra™ is designed to deliver iron differently—using a thoughtful formulation, carefully selected ingredients, and a clinically informed approach to absorption and tolerance.
How quickly can patients expect to see improvement in iron levels?
TruFerra™ is clinically shown to increase iron levels by more than 100% in six weeks, with levels sustained at 12 weeks. Energy improvements will be seen within six weeks.
What is the recommended dosing protocol for TruFerra™?
The recommended dose for TruFerra™ is one capsule per day.
Can I recommend TruFerra™ during pregnancy and postpartum?
Yes, TruFerra™ delivers 30 mg of iron per capsule, meeting WHO requirements for pregnancy (30-60 mg/day during pregnancy). The formula's enhanced tolerability makes it ideal for pregnant patients with GI sensitivity. WHO recommends continuing supplementation for six to 12 weeks postpartum.
What makes TruFerra™ more bioavailable?
Unlike other supplemental iron, TruFerra™ contains the patent-protected ST1406® formula that delivers iron in its ideal ferrous (Fe2+) form to DMT-1 transporters in the duodenum for optimal absorption.
® formula that delivers iron in its ideal ferrous (Fe2+) form to DMT-1 transporters in the duodenum for optimal absorption.
Confidently Recommend TruFerra™
TruFerra™ is engineered to improve absorption, tolerability, and adherence—supporting sustained iron repletion and meaningful patient-reported outcomes.
TruFerra™ is exclusively distributed by Ortho Molecular Products.
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